WT1 Antibody (DA119)

Description

Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed in tissues of mesodermal origin.1 The Wilms’ tumor gene encodes a protein that functions as a tumor suppressor gene mapped to human chromosome 11p13.2 Nuclear WT1 immunoreactivity has been observed in high frequencies in several types of mesoderm-derived tumors including epithelioid mesothelioma and ovarian serous carcinoma, and thus is used as a marker for these neoplasms.2,3,6 — Références — 1. May RJ, et al. Peptide epitopes from the Wilms' tumor 1 oncoprotein stimulate CD4+ and CD8+ T cells that recognize and kill human malignant mesothelioma tumor cells. Clin Cancer Res. 2007; 13: 4547-55. 2. Ghanem MA, et al. Expression and prognostic value of Wilms' tumor 1 and early growth response 1 proteins in nephroblastoma. Clin Cancer Res 2000; 6(11):4265-71. 3. Al-Hussaini M, et al. WT-1 assists in distinguishing ovarian from uterine serous carcinoma and in distinguishing between serous and endometrioid ovarian carcinoma. Histopathology 2004; 44(2):109-15. 4. Maki T, et al. Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification. Int J Oncol 2017; 50(1):129-140. 4. Galfione SK, et al. Diagnostic utility of WT-1 cytoplasmic stain in variety of vascular lesions. Int J Clin Exp Pathol 2014; 7(5):2536-43. 6. Köbel M, et al. An immunohistochemical algorithm for ovarian carcinoma typing. Int J Gynecol Pathol 2016; 35(5):430-41

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA119

Isotype

Rabbit

Réactivité

Synthetic peptide of human WT1

Localisation

Nucleus

Usage prévu

IHC (FFPE)