Vimentin Antibody (DA118)

Description

Anti-vimentin recognizes a 57-kDa intermediate filament initially isolated from mouse fibroblast culture. Anti-vimentin often serves as a useful control marker to ensure that the tissue has been properly preserved and processed.1 Expression of vimentin, when used in conjunction with keratin, is helpful when distinguishing melanomas from undifferentiated carcinomas and large cell lymphomas. All melanomas and schwannomas react strongly with vimentin. It labels a variety of mesenchymal cells, including melanocytes, lymphocytes, endothelial cells, and fibroblasts. In the area of gynecologic tumors, uterine endometrioid adenocarcinomas display a highly characteristic immunophenotype, with coexpression of low molecular wt. cytokeratin and vimentin.1-4 — Références — 1. Dabbs DJ. Diagnostic Immunohistochemistry. Third Edition. Philadelphia, PA: Saunders/Elsevier. 2010. Print. 2. Dabbs DJ, et al. Hum Pathol. 1996; 27:172-7. 3. Dabbs DJ, et al. Am J Surg Pathol. 1986; 10:568-76. 4. Yaziji H, et al. Int J Gynecol Pathol. 2001; 20:64-78.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA118

Isotype

Rabbit

Réactivité

Synthetic peptide from human vimentin

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)