Villin Antibody (DA117)

Description

Villin is a 95 kD glycoprotein of microvilli associated with rootlet formation in gastrointestinal mucosal epithelium. Anti-villin labels the brush border area in the gastrointestinal mucosal epithelium.1 This antibody has been useful in differentiating gastrointestinal adenocarcinoma, neuroendocrine carcinomas, and ovarian adenocarcinomas from adenocarcinomas of other organs.2-5 This antibody also labels Merkel cells of the skin.6 — Références — 1. Leong AS-Y, et al. Manual of diagnostic antibodies for immnunohistochemistry. London: Greenwich Medical Media Ltd. 1999. Print. p. 162-168. 2. Tan J, et al. Villin, cytokeratin 7, and cytokeratin 20 expression in pulmonary adenocarcinoma with ultrastructural evidence of microvilli with rootlets. Hum Pathol. 1998; 29:390-6. 3. Goldstein NS, et al. Mucinous and nonmucinous bronchioloalveolar adenocarcinomas have distinct staining patterns with thyroid transcription factor and cytokeratin 20 antibodies. Am J Clin Pathol. 2001; 116:319-25. 4. Tamboli P, et al. Colonic adenocarcinoma metastatic to the urinary tract versus primary tumors of the urinary tract with glandular differentiation: a report of 7 cases and investigation using a limited immunohistochemical panel. Arch Pathol Lab Med. 2002; 126:1057-63. 5. Zhang PJ, et al. Immunoexpression of villin in neuroendocrine tumors and its diagnostic implications. Arch Pathol Lab Med. 1999; 123:812-6. 6. Toyoshima K, et al. Identification of Merkel cells by an antibody to villin. J Histochem Cytochem. 1998; 46:1329-34.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA117

Isotype

Rabbit

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)