TTF-1 Antibody (DA116)

Description

Thyroid transcription factor-1 (TTF-1) is a transcription factor that plays a role in regulating genes expressed within the thyroid, lung, and brain. TTF-1 expression is present in normal thyroid epithelium and type II pneumocytes and nonciliated bronchiolar secretory cells of the lung. TTF-1 expression is seen in most primary lung and thyroid carcinomas, but rarely in other carcinomas. Anti-TTF-1 immunohistochemistry is useful for identifying carcinomas of thyroid and lung origin. 1-9 — Références — 1. Bejarano, P A et al. "Surfactant proteins and thyroid transcription factor-1 in pulmonary and breast carcinomas." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 9,4 (1996): 445-52. 2. Holzinger, A et al. "Monoclonal antibody to thyroid transcription factor-1: production, characterization, and usefulness in tumor diagnosis." Hybridoma vol. 15,1 (1996): 49-53. 3. Saad, Reda S et al. "Utility of immunohistochemistry in separating thymic neoplasms from germ cell tumors and metastatic lung cancer involving the anterior mediastinum." Applied immunohistochemistry & molecular morphology : AIMM vol. 11,2 (2003): 107-12. 4. Di Loreto, C et al. "Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma." Journal of clinical pathology vol. 50,1 (1997): 30-2. 5. Abutaily, A S et al. "Immunohistochemistry in the distinction between malignant mesothelioma and pulmonary adenocarcinoma: a critical evaluation of new antibodies." Journal of clinical pathology vol. 55,9 (2002): 662-8. 6. Di Loreto, C et al. "Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma." Journal of clinical pathology vol. 50,1 (1997): 30-2. 7. Katoh, R et al. "Thyroid transcription factor-1 in normal, hyperplastic, and neoplastic follicular thyroid cells examined by immunohistochemistry and nonradioactive in situ hybridization." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 13,5 (2000): 570-6. 8. Jang, K Y et al. "Utility of thyroid transcription factor-1 and cytokeratin 7 and 20 immunostaining in the identification of origin in malignant effusions." Analytical and quantitative cytology and histology vol. 23,6 (2001): 400-4. 9. Srodon, M, and W H Westra. "Immunohistochemical staining for thyroid transcription factor-1: a helpful aid in discerning primary site of tumor origin in patients with brain metastases." Human pathology vol. 33,6 (2002): 642-5.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA116

Isotype

Mouse

Réactivité

Synthetic peptide from human TTF-1

Localisation

Nucleus

Usage prévu

IHC (FFPE)