TROP2 Antibody (DA242)

Description

Trophoblast antigen 2 (TROP2) is a transmembrane glycoprotein that transduces intracellular calcium signals1. The overexpression of TROP2 has been linked to tumor progression due to its involvement in the regulation of multiple vital cell processes including migration, proliferation, and invasion2. TROP2 exhibits strong, diffuse staining in papillary thyroid carcinoma, while staining in other thyroid lesions, such as follicular thyroid adenomas and carcinomas, is limited to rare, focal, or scattered cells3,4. An increase in TROP2 expression has also been observed in colorectal carcinomas and ovarian serous carcinomas compared to non-neoplastic ovary and colon5. — Références — 1. Ripani E, et al. Human TROP-2 is a tumor-associated calcium signal transducer. Int J Cancer. 1998;76(5):671-676 2. Wu B, et al. Overexpression of TROP2 promotes proliferation and invasion of ovarian cancer cells. Exp Ther Med. 2017;14(3):1947-1952 3. Bychkov A, et al. TROP-2 immunohistochemistry: a highly accurate method in the differential diagnosis of papillary thyroid carcinoma. Pathology. 2016;48(5):425-433 4. Liu H, et al. The Potential Diagnostic Utility of TROP-2 in Thyroid Neoplasms. Appl Immunohistochem Mol Morphol. 2017;25(8):525-533 5. Stephan LP, et al. Expression of Trop2 Cell Surface Glycoprotein in Normal and Tumor Tissues. J Histochem Cytochem. 2011;59(7):701-710

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA242

Isotype

Rabbit

Réactivité

Synthetic peptide of human TROP2

Localisation

Cell membrane

Usage prévu

IHC (FFPE)