TIA-1 Antibody (DA112)

Description

TIA-1 (T-cell intracytoplasmic antigen) is a 15 kDa cytoplasmic granule-associated protein, expressed in lymphocytes processing cytolytic potential. TIA-1 is a member of an RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15 kDa protein thought to be derived from the carboxyl terminus of the 40 kDa product by proteolytic processing.The expression of TIA-1 has been studied in anaplastic large cell lymphomas (ALCL), NK-cell lymphomas, peripheral T-cell lymphomas, T-cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, and Hodgkin’s lymphoma, etc. Studies show that 60 to 70% of anaplastic large cell lymphomas react with TIA-1. TIA-1 also reacts with most large granular lymphocytic leukemias, hepatosplenic T-cell lymphomas, intestinal T-cell lymphomas, NK-like T-cell lymphomas, NK-cell lymphomas, nasal T/NK-cell lymphomas, subcutaneous T-cell lymphomas and pulmonary angiocentric lymphomas of T-or NK-phenotype. All B-cell lymphomas, Hodgkin’s and lymphoblastic leukemias are negative for TIA-1.1-5 — Références — 1. Dukers DF, ten Berge RL, Oudejans JJ, et al. A cytotoxic phenotype does not predict clinical outcome in anaplastic large cell lymphomas. J Clin Pathol. 1999;52(2):129-136. doi:10.1136/jcp.52.2.129 2. Hatano B, Ohshima K, Katoh A, et al. Non-HTLV-1-associated primary gastric T-cell lymphomas show cytotoxic activity: clinicopathological, immunohistochemical characteristics and TIA-1 expression in 31 cases. Histopathology. 2002;41(5):421-436. doi:10.1046/j.1365-2559.2002.01459.x 3. Kanavaros P, Vlychou M, Stefanaki K, et al. Cytotoxic protein expression in non-Hodgkin's lymphomas and Hodgkin's disease. Anticancer Res. 1999;19(2A):1209-1216. 4. Mori N, Murakami YI, Shimada S, et al. TIA-1 expression in hairy cell leukemia. Mod Pathol. 2004;17(7):840-846. doi:10.1038/modpathol.3800129 5. U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories. Supplement / Vol. 61, January 6, 2012. https://www.cdc.gov/mmwr/pdf/other/su6101.pdf

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA112

Isotype

Mouse

Réactivité

Synthetic peptide of human TIA-1

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)