Thyroglobulin Antibody (DA111)

Description

Thyroglobulin (Tg) is the precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).1 Tg is a high molecular weight glycoprotein found in normal thyroid follicular cells.1,2 Thyroglobulin is useful for identifying thyroid carcinoma of papillary and follicular types and for identifying tumors of thyroid origin when working with adenocarcinoma of unknown primary.2-5 — Références — 1. Sellitti DF, et al. Intrinsic regulation of thyroid function by thyroglobulin. Thyroid. 2014; 24:625-38. 2. Bellet D, et al. Production and in vitro utilization of monoclonal antibodies to human thyroglobulin. J Clin Endocrinol Metab. 1983; 56:530-3. 3. Bejarano PA, et al. Thyroid transcription factor-1, thyroglobulin, cytokeratin 7, and cytokeratin 20 in thyroid neoplasms. Appl Immunohistochem Mol Morphol. 2000; 8:189-94. 4. Judkins AR, et al. Utility of immunohistochemistry in the evaluation of necrotic thyroid tumors. Hum Pathol. 1999; 30:1373-6. 5. Hammer SP. Metastatic adenocarcinoma of unknown primary origin. Hum Pathol. 1998; 29:1393-402.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA111

Isotype

Rabbit

Réactivité

Synthetic peptide of human Thyroglobulin

Localisation

Nucleus

Usage prévu

IHC (FFPE)