TFE3 Antibody (DA110)

Description

Transcription factor E3 (TFE3) is a protein expressed in many cell types that are encoded by the TFE3 gene. This gene may be involved in chromosomal translocations that occur in some cancers.Xp11 translocation renal cell carcinomas (RCC) are a recently recognized subset of RCC, characterized by chromosome translocations involving the Xp11.2 break point and resulting in gene fusions involving the TFE3 transcription factor gene that maps to this locus.1 Alveolar soft part sarcoma (ASPS) is an uncommon soft tissue sarcoma of uncertain differentiation. The hallmark of ASPS is a chromosomal rearrangement at 17q25 and Xp11.2 engendering an ASPSCR1-TFE3 fusion gene responsible for an aberrant transcription factor presumably enabling pathogenesis.1-5 — Références — 1. Argani P. The evolving story of renal translocation carcinomas. Am J Clin Pathol. 2006; 126:332-4. 2. Argani P, et al. Aberrant nuclear immunoreactivity for TFE3 in neoplasms with TFE3 gene fusions: a sensitive and specific immunohistochemical assay. Am J SurgPathol. 2003; 27:750-61. 3. Argani P, et al. Translocation carcinomas of the kidney.Clin Lab Med.2005; 25:363-78. 4. Lazar AJ, et al. Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray. Histopathol. 2009; 55:750-5. 5. Lin G, et al. An update on the application of newly described immunohistochemical markers in soft tissue pathology. Arch Pathol Lab Med. 2015; 139:106-21.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA110

Isotype

Rabbit

Réactivité

Synthetic peptide of human TFE3

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)