TdT Antibody (DA109)

Description

TdT (terminal deoxynucleotidyl transferase) is a template-independent DNA polymerase that adds nucleotides randomly to single-stranded DNA. This randomization plays a role in acquired immunity by increasing antigen receptor diversity and aiding in the generation of immunoglobulins and T-cell antigen receptors.1 TdT expression is characteristic of lymphoid progenitor cells in thymus and tonsils.2 Anti-TdT is a useful marker for lymphoblastic lymphomas3 and has been observed in some cases of acute myeloid leukemia.4 — Références — 1. Motea EA, et al. Terminal deoxynucleotidyl transferase: the story of a misguided DNA polymerase. Biochimica et Biophysica Acta. 2010; 1804:1151-66. 2. Stauchen JA, et al. Lymphoid progenitor cells in human tonsils. Int J Surg Pathol. 2003; 11:21-4. 3. Suzumiya J, et al. Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. J Pathol. 1997; 182:86-91. 4. Arber DA, et al. Paraffin section immunophenotyping of acute leukemias in bone marrow specimens. Am J Clin Pathol. 1996; 106:462-8.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA109

Isotype

Rabbit

Réactivité

Synthetic peptide of human TdT

Localisation

Nucleus

Usage prévu

IHC (FFPE)