Synaptophysin Antibody (DA108)

Description

Syn (synaptophysin), also known as the major synaptic vesicle protein p38, is a protein that in humans is encoded by the SYP gene. Anti-synaptophysin reacts with neuroendocrine cells of human adrenal medulla, pituitary, thyroid, lung, pancreas, and gastrointestinal mucosa. Positive staining is seen in neurons of the brain. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms.1-5 Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Anti-synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.1-9 — Références — 1. Navone F, Jahn R, Di Gioia G, Stukenbrok H, Greengard P, De Camilli P. Protein p38: an integral membrane protein specific for small vesicles of neurons and neuroendocrine cells. J Cell Biol. 1986 Dec;103(6 Pt 1):2511-27. 2. Wiedenmann B, Franke WW. Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles. Cell. 1985 Jul;41(3):1017-28. 3. Kayser K, Schmid W, Ebert W, Wiedenmann B. Expression of neuroendocrine markers (neuronspecific enolase, synaptophysin and bombesin) in carcinoma of the lung. Pathol Res Pract. 1988 Aug;183(4):412-7. 4. Son EI, Kim IM, Kim DW, Yim MB, Kang YN, Lee SS, Kwon KY, Suh SI, Kwon TK, Lee JJ, Kim DS, Kim SP. Immunohistochemical analysis for histopathological subtypes in pediatric medulloblastomas. Pathol Int. 2003 Feb;53(2):67-73. 5. Conner MG, Richter H, Moran CA, Hameed A, Albores-Saavedra J. Small cell carcinoma of the cervix: a clinicopathologic and immunohistochemical study of 23 cases. Ann Diagn Pathol. 2002 Dec;6(6):345-8. 6. Lyda MH, Weiss LM. Immunoreactivity for epithelial and neuroendocrine antibodies are useful in the differential diagnosis of lung carcinomas. Hum Pathol. 2000 Aug;31(8):980-7. 7. Skacel M, Ormsby AH, Petras RE, McMahon JT, Henricks WH. Immunohistochemistry in the differential diagnosis of acinar and endocrine pancreatic neoplasms. Appl Immunohistochem Mol Morphol. 2000 Sep;8(3):203-9. 8. Morrison CD, Prayson RA. Immunohistochemistry in the diagnosis of neoplasms of the central nervous system. Semin Diagn Pathol. 2000 Aug;17(3):204-15. 9. Kamisawa T, Fukayama M, Tabata I, Isawa T, Tsuruta K, Okamoto A, Koike. Neuroendocrine differentiation in pancreatic duct carcinoma special emphasis on duct-endocrine cell carcinoma of the pancreas. Pathol Res Pract. 1996 Sep;192(9):901-8.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA108

Isotype

Rabbit

Réactivité

Synthetic peptide from human synaptophysin

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)