Dartmon STAT6 Antibody (DA215)
IHC (FFPE)
Description
STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors.1-3 Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm.1 STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays.1 NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas.1-3 This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors. — Références — 1. Cheah AL, et al. Pathology. 2014; 46:389-95. 2. Schweizer L, et al. Acta Neuropathol. 2013; 125:651-58. 3. Koelsche C, et al. Histopathology. 2014; 65:613-22.
Caractéristiques
- Type
- Recombinant monoclonal mouse antibody
- Clone
- DA215
- Isotype
- Mouse
- Réactivité
- Synthetic peptide of human STAT6
- Localisation
- Cytoplasm/Nucleus
- Usage prévu
- IHC (FFPE)
Conditionnements disponibles
2 référence(s) catalogue.
| N° catalogue | Type | Dilution | Volume | |
|---|---|---|---|---|
| DMRD0265 | Concentrate | 1:100 – 1:200 | 0.1ml, 0.5ml, 1ml | Demander un devis → |
| DMRD0265 | Ready to use | 1:100 – 1:200 | 3ml, 6ml, 10ml | Demander un devis → |
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