SOX-11 Antibody (DA135)

Description

SOX-11 which is a member of the SOX (SRY-related HMG-box) family is a transcription factor normally expressed in the developing human central nervous system and plays a role in embryonic cell determination.1,3 Studies show that SOX-11 can be used as a marker for mantle cell lymphoma (MCL).2,3 — Références — 1. Hargrave, M et al. Expression of the SOX-11 gene in mouse embryos suggests roles in neuronal maturation and epithelio-mesenchymal induction. Dev Dyn 1997; 210:79-86. 2. Zeng W, et al. Cyclin D1-negative blastoid mantle cell lymphoma identified by SOX-11 expression. Am J Surg Pathol 2012; 36:214-9. 3. Narurkar R, et al. SOX11 is a biomarker for cyclin D1-negative mantle cell lymphoma. Biomark Res. 2016; 4:6.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA135

Isotype

Rabbit

Réactivité

Synthetic peptide of human SOX-11

Localisation

Nucleus

Usage prévu

IHC (FFPE)