SOX-10 Antibody (DA214)

Description

Sry-related HMG-BOX gene 10, SOX-10, is a transcription factor involved in neural crest and peripheral nervous system development, and acts as a nucleocytoplasmic shuttle protein.1 SOX-10 is expressed in melanocytic lineages, and is a sensitive marker of melanoma for conventional, and desmoplastic subtypes.2-3 In normal tissues, SOX-10 is expressed in melanocytes, and myoepithelial cells.4 — Références — 1. Rehberg S, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol Cell Biol. 2002; 22:5826-34. 2. Nonaka D, et al. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol. 2008; 32:1291-8. 3. Nielsen TO, et al. Sox10 and S100 in the diagnosis of soft-tissue neoplasms. Appl Immunohistochem Mol Morphol. 2012; 20:445-50. 4. Miettinen M, et al. Sox10--a marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue: a systematic analysis of 5134 tumors. Am J Surg Pathol. 2015; 39:826-35.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA214

Isotype

Rabbit

Réactivité

Synthetic peptide of human SOX-10

Localisation

Nucleus

Usage prévu

IHC (FFPE)