SMA Antibody (DA107)

Description

Actin proteins are major components of the eukaryotic cytoskeleton. At least six vertebrate actin isoforms have been identified. The cytoplasmic β- and γ-actin proteins are referred to as “non-muscle” actin proteins as they are predominantly expressed in non-muscle cells where they control cell structure and motility. The α-cardiac and α-skeletal actin proteins are expressed in striated cardiac and skeletal muscles, respectively. The smooth muscle α-actin and γ-actin proteins are found primarily in vascular smooth muscle and enteric smooth muscle, respectively. The α-smooth muscle actin (ACTA2) is also known as aortic smooth muscle actin. These actin isoforms regulate the contractile potential of muscle cells 1. — Références — 1. Herman, I.M. (1993) Curr Opin Cell Biol 5, 48-55.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA107

Isotype

Mouse

Réactivité

Synthetic peptide from human SMA

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)