S100 Antibody (DA105)

Description

S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells.1,2,6 Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly.1-4 A large number of well differentiated tumors of the salivary gland, adipose and cartilaginous tissue, 3 and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.4,5 Despite the fact that S-100 protein is an ubiquitous substance, its demonstration is of great value in the identification of several neoplasms, particularly melanomas.1-6 — Références — 1. Nakajima T, et al. Ad J Surg Path. 1982; 6:715-727. 2. Kuhn HJ, et al. Am J Clin Path. 1983; 79:341-347. 3. Monda L, et al. Hum Pathol. 1985; 16:287-293. 4. Yaziji H, et al. Int J Surg Pathol. 2003; 11:11-5. 5. Patel P, et al. J Am Acad Dermatol. 2002; 46:264-70. 6. Morrison CD, et al. Semin Diagn Pathol. 2000; 17:204-15.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA105

Isotype

Mouse

Réactivité

Synthetic peptide from human S100

Localisation

Cytoplasm/Nucleus

Usage prévu

IHC (FFPE)