PSMA Antibody (DA104)

Description

Prostate-specific membrane antigen (PSMA) is a type II transmembrane glycoprotein with enzymatic activity.1,2 PSMA is expressed in normal prostate epithelial cells as well as prostate neoplastic cells. It has been demonstrated that PSMA expression is increased in prostate cancer and is correlated with disease progression.2 Although highly sensitive and specific for prostate, PSMA also labels a subset of non-prostate tissues, including the small intestine and kidney.2,3 PSMA is useful for identifying metastatic prostate carcinoma4 and distinguishing prostate carcinoma from urothelial carcinoma.5 — Références — 1. Ghosh A, et al. Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer. J Cell Biochem. 2004; 91(3):528-39. 2. Chang SS. Overview of Prostate-Specific Membrane Antigen. Rev Urol. 2004; 6 (Suppl 10):S13-8. 3. Silver DA, et al. Prostate-specific membrane antigen expression in normal and malignant human tissues. Clin Cancer Res. 1997; 3:81-5. 4. Bernacki KD, et al. The utility of PSMA and PSA immunohistochemistry in the cytologic diagnosis of metastatic prostate carcinoma. Diagn Cytopathol. 2014; 42(7):570-5. 5. Oh WJ, et al. Differential immunohistochemical profiles for distinguishing prostate carcinoma and urothelial carcinoma. J Pathol Transl Med. 2016; 50(5):345-54.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA104

Isotype

Rabbit

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)