Progesterone Receptor Antibody (DA201)

Description

PR is a nuclear hormone receptor that activates transcription of various genes, especially in reproductive tissues, regulated by its ligand progesterone. Two isoforms exist : PR-A (94 kDa) and PR-B (114 kDa). Antibody PR detects both isoforms. Ratio of these isoforms varies in reproductive tissues and during carcinogenesis. The antibody labels cells in breast, ovary and uterus, and is an important marker for detection of breast cancer. 1-4 — Références — 1. Mulac-Jericevic B, Conneely OM (2004): Reproductive tissue selective actions of progesterone receptors. Reproduction. 128(2): 139-146. 2. Duffy MJ, Harbeck N, Nap M et al. (2017): Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM). Eur J Cancer. 75: 284-298. 3. Schettini F, Buono G, Cardalesi C et al. (2016): Hormone Receptor/Human Epidermal Growth Factor Receptor 2-positive breast cancer: Where we are now and where we are going. Cancer Treat Rev. 46: 20-26. 4. Wei LL, Miner R (1994): Evidence for the existence of a third progesterone receptor protein in human breast cancer cell line T47D. Cancer Res. 54(2): 340-343.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA201

Isotype

Mouse

Réactivité

Synthetic peptide from human Progesterone Receptor

Localisation

Nucleus

Usage prévu

IHC (FFPE)