Podoplanin Antibody (DA051)

Description

Podoplanin is a transmembrane mucoprotein (38 kD) recognized by the D2-40 monoclonal antibody. Podoplanin is selectively expressed in normal and malignant lymphatic endothelium, including Kaposi’s sarcomas. Podoplanin has also been shown to be expressed in epithelioid mesotheliomas and seminomas. It is helpful in the diagnosis of lymphatic endothelium-derived tumors and in determining the occurrence of lymphatic infiltration and metastasis in other tumor tissues.1-9 — Références — 1. Ordóñez NG. Podoplanin: a novel diagnostic immunohistochemical marker. Adv Anat Pathol. 2006; 13:83-8. 2. Ordóñez N. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Hum Pathol. 2005; 36:372-80. 3. Niakosari F, et al. Detection of lymphatic invasion in primary melanoma with monoclonal antibody D2-40: a new selective immunohistochemical marker of lymphatic endothelium. Arch Dermatol. 2005; 141:440-4. 4. Galambos C, et al. Identification of lymphatic endothelium in pediatric vascular tumors and malformations. Pediatr Dev Pathol. 2005; 8:181-9. 5. Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology. 2005; 46:396-402. 6. Chu AY, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol. 2005; 18:105-10. 7. Franke FE, et al. Hobnail hemangiomas (targetoid hemosiderotic hemangiomas) are true lymphangiomas. J Cutan Pathol. 2004; 31:362-7. 8. Fogt F, et al. Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep. 2004; 11:47-50. 9. Kahn HJ, et al. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 2002; 15:434-40.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA051

Isotype

Mouse

Réactivité

Synthetic peptide from human podoplanin

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)