PD-1 Antibody (DA196)

Description

Programmed death-1 (PD-1) is a type-I transmembrane protein expressed on T-cells, B-cells, and monocytes during activation.1-2 PD-1 and its ligands (PD-L1 and PD-L2) function as an immune checkpoint pathway by regulating T-cell activation and autoimmunity.2 PD-1 labels follicular helper T-cells and is therefore a useful marker for angioimmunoblastic T-cell lymphoma.3-4 It is mainly used in follicular lymphoma and other low-grade malignant medium and small B-cell lymphomas, renal clear cell carcinoma and other clear cell carcinomas of origin, endometrial stromal sarcoma and uterine leiomyosarcoma. — Références — 1. Thibult ML, et al. PD-1 is a novel regulator of human B-cell activation. Int Immunol. 2013; 25:129-37. 2. Francisco L, et al. The PD-1 pathway in tolerance and autoimmunity. Immunol. 2010; 236:219-42. 3. Dorfman DM, et al. Programmed Death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell Lymphoma. Am J Surg Pathol. 2006; 30:802-10. 4. Cogbill CH, et al. Utility of CD279/PD-1 immunohistochemistry in the evaluation of benign and neoplastic T-cell-rich bone marrow infiltrates. Am J Clin Pathol. 2014; 142:88-98.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA196

Isotype

Mouse

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)