Pax-8 Antibody (DA099)

Description

PAX-8 is a transcription factor expressed during embryonic development of Müllerian organs, kidney, and thyroid, with continued expression in some epithelial cell types of these mature tissues.1 PAX-8 is a useful marker for neoplasms of gynecologic,2,5,7,10 renal,3-9 and thyroid origin.1,4,5,7 — Références — 1. Nonaka, Daisuke et al. "Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 21,2 (2008): 192-200. 2. Nonaka, Daisuke et al. "Expression of pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas." The American journal of surgical pathology vol. 32,10 (2008): 1566-71. 3. Tong, Guo-Xia et al. "Expression of PAX8 in normal and neoplastic renal tissues: an immunohistochemical study." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 22,9 (2009): 1218-27. 4. Ozcan, Ayhan et al. "PAX 8 expression in non-neoplastic tissues, primary tumors, and metastatic tumors: a comprehensive immunohistochemical study." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 24,6 (2011): 751-64. 5. Laury, Anna R et al. "A comprehensive analysis of PAX8 expression in human epithelial tumors." The American journal of surgical pathology vol. 35,6 (2011): 816-26. 6. Sangoi, Ankur R et al. "Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 cases." The American journal of surgical pathology vol. 35,5 (2011): 678-86. 7. Ordóñez, Nelson G. "Value of PAX 8 immunostaining in tumor diagnosis: a review and update." Advances in anatomic pathology vol. 19,3 (2012): 140-51. 8. Mentrikoski, Mark J et al. "Immunohistochemical distinction of renal cell carcinoma from other carcinomas with clear-cell histomorphology: utility of CD10 and CA-125 in addition to PAX-2, PAX-8, RCCma, and adipophilin." Applied immunohistochemistry & molecular morphology : AIMM vol. 22,9 (2014): 635-41. 9. Barr, Meaghan L et al. "PAX-8 expression in renal tumours and distant sites: a useful marker of primary and metastatic renal cell carcinoma?." Journal of clinical pathology vol. 68,1 (2015): 12-7. 10. Espinosa, Inigo et al. "Simultaneous carcinomas of the breast and ovary: utility of Pax-8, WT-1, and GATA3 for distinguishing independent primary tumors from metastases." International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists vol. 34,3 (2015): 257-65.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA099

Isotype

Mouse

Réactivité

Synthetic peptide from human Pax-8

Localisation

Nucleus

Usage prévu

IHC (FFPE)