Pax-5 Antibody (DA098)

Description

PAX-5 encodes for B-cell-specific activator protein (BSAP), a marker for B-cells, including B-lymphoblastic neoplasms and maturation stage. It is found in most cases of mature and precursor B-cell non-Hodgkin lymphomas/leukemias. In approximately 97% of cases of classic Hodgkin lymphoma, Reed-Sternberg cells express PAX-5.4 PAX-5 is not detected in multiple myeloma and solitary plasmacytoma, making it useful for such differentiation.1,3 Diffuse large B-cell lymphomas do express PAX-5, save for those with terminal B-cell differentiation. T-cell neoplasms do not stain with anti-PAX-5. There is a strong association with CD20 expression.1-4 — Références — 1. Torlakovic E, et al. Am J Surg Pathol. 2002; 26:1343-50. 2. Willenbrock K, et al. Lab Invest. 2002; 82:1103-9. 3. Falini B, et al. Blood. 2002; 99:409-26. 4. Schwering I, et al. Blood. 2003; 101:1505-12.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA098

Isotype

Rabbit

Réactivité

Synthetic peptide from human Pax-5

Localisation

Nucleus

Usage prévu

IHC (FFPE)