p16 Antibody (DA093)

Description

p16 is a protein that slows cell division by slowing the progression of the cell cycle from G1 phase to S phase, thereby acting as a tumor suppressor. Deletion in this gene can result in insufficient or nonfunctional p16, thereby accelerating the cell cycle and causing many types of cancer. p16 can be used as a biomarker to improve the histological diagnostic accuracy of grade 3 cervical intraepithelial neoplasia (CIN). Expression of p16 (p16-positive) is highly correlated with human papillomavirus (HPV) infection in head and neck squamous cell carcinoma (HNSCC). p16 is also involved in the prevention of melanoma, oropharyngeal squamous cell carcinoma, cervical cancer, vulvar cancer, and esophageal cancer. 1-4 — Références — 1. Dray M, et al. p16(INK4a) as a complementary marker of high-grade intraepithelial lesions of the uterine cervix. I: Experience with squamous lesions in 189 consecutive cervical biopsies. Pathology. 2005 Apr;37(2):112-24. 2. Klaes R, et al. Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer. 2001 Apr 15;92(2):276-84. 3. Negri G, et al. p16 ink4a and HPV L1 immunohistochemistry is helpful for estimating the behavior of low-grade dysplastic lesions of the cervix uteri. At J Surg Pathol. 2008 Nov;32(11):1715-20. 4. Ordi J, et al. p16 INK4a immunostaining identifies occult CIN lesions in HPV-positive women. Int J Gynecol Pathol. 2009 Jan;28(1):90-7.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA093

Isotype

Mouse

Réactivité

Synthetic peptide from human p16

Localisation

Cytoplasm/Nucleus

Usage prévu

IHC (FFPE)