NSE Antibody (DA091)

Description

Neuron-specific enolase (NSE) is a glycolytic isoenzyme of the enolase gamma-gamma dimer selectively detected in neurons, peripheral nerves, some neuroendocrine cells and tumors.1-3. NSE immunoreactivity is also observed, to a lesser extent, in smooth muscle tissue.4 Anti-NSE is often used to visualize peripheral nerves and for the identification of neuroendocrine differentiation.5 — Références — 1. Wick MR, et al. Neuron-specific enolase in neuroendocrine tumors of the thymus, bronchus and skin. Am J Clin Pathol. 1983; 79:703-7. 2. Vinores SA, et al. Immunohistochemical demonstration of neuron-specific enolase in neoplasms of the CNS and other tissues. Arch Pathol Lab Med. 1984; 108:536-40. 3. Leong AS, et al. Criteria for the diagnosis of primary endocrine carcinoma of the skin (Merkel cell carcinoma). A histological, immunohistochemical and ultrastructural study of 13 cases. Pathology. 1986; 18:393-9. 4. Cooper EH. Neuron-specific enolase. Int J Biol Markers. 1994; 9:205-10. 5. Leonard N, et al. Neuroproliferation in the mucosa is a feature of coeliac disease and Crohn's disease. Gut. 1995; 37:763-5.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA091

Isotype

Mouse

Réactivité

Synthetic peptide of human NSE

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)