NKX2.2 Antibody (DA235)

Description

NKX2.2 is a homeodomain transcription factor that plays a role in neuroendocrine and glial differentiation.1 NKX2.2 is upregulated in Ewing’s sarcoma as a result of the oncogenic EWS-FLI1 fusion protein.2,3 As one of many small round blue cell tumors, Ewing’s sarcoma can be difficult to diagnose due to the characteristic undifferentiated morphology.4 NKX2.2 has proven its utility as a sensitive maker for distinguishing Ewing’s sarcoma from other round blue cell tumors when used in a panel.1,5 — Références — 1. Yoshida A, et al. Am J Surg Pathol. 2012; 36:993-9. 2. Yamamoto Y, et al. J Cytol. 2015; 32:30-32. 3. Smith R, et al. Cancer Cell. 2006; 9:405-16. 4. Rajwanshi A, et al. J Cytol. 2009; 26:1-10. 5. Hung Y, et al. Mod Pathol. 2016; 29:370-80.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA235

Isotype

Rabbit

Réactivité

Synthetic peptide of human NKX2.2

Localisation

Nucleus

Usage prévu

IHC (FFPE)