Napsin A Antibody (DA090)

Description

Napsin is a pepsin-like aspartic protease, and there are two closely related Napsins, NapsinA and NapsinB. NapsinA is a single-chain protein with a molecular weight close to 38 KDa.1-3 It is highly expressed in human lung and kidney, and low in spleen. Napsin A is involved in processing propeptide pulmonary surfactant protein B (proSP-B) in the lung.4 In normal, benign tissue, Napsin A is expressed in type II pneumocytes of the lung and proximal tubules of the kidney. Napsin A is a useful marker for lung adenocarcinoma.1-3, 5-8 — Références — 1. Jagirdar, Jaishree. "Application of immunohistochemistry to the diagnosis of primary and metastatic carcinoma to the lung." Archives of pathology & laboratory medicine vol. 132,3 (2008): 384-96. 2. Bishop, Justin A et al. "Napsin A and thyroid transcription factor-1 expression in carcinomas of the lung, breast, pancreas, colon, kidney, thyroid, and malignant mesothelioma." Human pathology vol. 41,1 (2010): 20-5. 3. Rawlings ND and Salvesen GS. Handbook of Proteolytic Enzymes Volume 1. 3rd Edition. Academic Press. 2013; p.69-71. 4. Brasch, Frank et al. "Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung." The Journal of biological chemistry vol. 278,49 (2003): 49006-14. 5. Dejmek, Annika et al. "Napsin A (TA02) is a useful alternative to thyroid transcription factor-1 (TTF-1) for the identification of pulmonary adenocarcinoma cells in pleural effusions." Diagnostic cytopathology vol. 35,8 (2007): 493-7. 6. Inamura, Kentaro et al. "Pulmonary adenocarcinomas with enteric differentiation: histologic and immunohistochemical characteristics compared with metastatic colorectal cancers and usual pulmonary adenocarcinomas." The American journal of surgical pathology vol. 29,5 (2005): 660-5. 7. Ye, Jiqing et al. "Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung." Applied immunohistochemistry & molecular morphology : AIMM vol. 19,4 (2011): 313-7. 8. Mukhopadhyay, Sanjay, and Anna-Luise A Katzenstein. "Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6." The American journal of surgical pathology vol. 35,1 (2011): 15-25.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA090

Isotype

Rabbit

Réactivité

Synthetic peptide of human Napsin A

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)