Myogenin Antibody (DA131)

Description

Myogenin also identified as myogenic factor 4 is a muscle specific transcription factor associated with muscle differentiation and cell cycle.1 Anti-myogenin reactivity is seen in the nuclei of myoblasts in developing muscle tissue. Anti-myogenin is a useful immunohistochemical reagent for identification of rhabdomyosarcoma.2-5 — Références — 1. Miller JB. Myogenic programs of mouse muscle cell lines: expression of myosin heavy chain isoforms, MyoD1, and myogenin. J Cell Biol. 1990; 111:1149-59. 2. Wang NP, et al. Expression of myogenic regulatory proteins (myogenin and MyoD1) in small blue round cell tumors of childhood. Am J Pathol. 1995; 147:1799-810. 3. Cui S, et al. Evaluation of new monoclonal anti-MyoD1 and anti-myogenin antibodies for the diagnosis of rhabdomyosarcoma. Pathol Int. 1999; 49:62-8. 4. Kaspar et al. The expression of c-Myb correlates with the levels of rhabdomyosarcoma-specific marker myogenin. Sci Rep. 2015; 5:15090. 5. Rudzinski et al. Myogenin, AP 2 Beta, NOS-1 and HMGA2 are surrogate markers of fusion status in rhabdomyosarcoma. Am J Surg Pathol. 2014; 38:654-9.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA131

Isotype

Mouse

Réactivité

Synthetic peptide of human Myogenin

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)