Myo D1 Antibody(DA088)

Description

MyoD1 is a phosphorylated protein with a molecular weight of 45kDa encoded by the MyoD gene, which is expressed only in embryonic rhabdomyosarcoma cells, but not in normal adult rhabdomyosarcoma cells. MyoD1, one of the MyoD family of myogenic helix-loop-helix transcription factors, combined with myogenin, plays a role in coordinating the differentiation of skeletal muscle. MyoD1 is expressed in myoblasts before differentiation. Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase.2 In conjunction with other markers, anti-MyoD1 may be used for identification of rhabdomyosarcoma.1,2 — Références — 1. Morotti, Raffaella A et al. "An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience." The American journal of surgical pathology vol. 30,8 (2006): 962-8. 2. Sebire, N J, and M Malone. "Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas." Journal of clinical pathology vol. 56,6 (2003): 412-6.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA088

Isotype

Rabbit

Réactivité

Synthetic peptide of human Myo D1

Localisation

Nucleus

Usage prévu

IHC (FFPE)