Myeloperoxidase Antibody (DA087)

Description

Myeloperoxidase (MPO) is a peroxidase that catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, producing a potent antimicrobial effect. Myeloperoxidase is present in granulocytes and monocytes and cells of myeloid lineage in the bone marrow. Anti-myeloperoxidase immunohistochemistry is useful for identification of benign and malignant myeloid cell populations, including acute myeloid leukemia.1-5 — Références — 1. Pinkus, G S, and J L Pinkus. "Myeloperoxidase: a specific marker for myeloid cells in paraffin sections." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 4,6 (1991): 733-41. 2. Markoc, Fatma et al. "Granulocytic sarcomas: difficulties in diagnosis." Tumori vol. 96,1 (2010): 149-53. 3. Alexiev, Borislav A et al. "Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study." Diagnostic pathology vol. 2 42. 31 Oct. 2007. 4. Saravanan, L, and S Juneja. "Immunohistochemistry is a more sensitive marker for the detection of myeloperoxidase in acute myeloid leukemia compared with flow cytometry and cytochemistry." International journal of laboratory hematology vol. 32,1 Pt 1 (2010): e132-6. 5. Manaloor, E J et al. "Immunohistochemistry can be used to subtype acute myeloid leukemia in routinely processed bone marrow biopsy specimens. Comparison with flow cytometry." American journal of clinical pathology vol. 113,6 (2000): 814-22.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA087

Isotype

Rabbit

Réactivité

Synthetic peptide from human Myeloperoxidase

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)