MSH2 Antibody (DA083)

Description

MSH2, also known as MutS homologue 2, is a key protein in DNA mismatch repair system. Mutations in MSH2 gene may lead to microsatellite instability (MSI) caused by accumulation of errors in DNA replication during cell proliferation. MSI is associated with Hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome), which is characterized by the development of colorectal cancer, endometrial cancer and various other tumors at early age. Antibody MSH2 is useful in detection of MSI, especially in a panel with MSH6, PMS2 and MLH1. 1-3 — Références — 1. Edelbrock MA, Kaliyaperumal S and Williams KJ(2013): Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activities. Mutat Res.743-744:53-66. 2. Vasen HF, Hendriks Y, de Jong AE et al. (2004): Identification of HNPCC by molecular analysis of colorectal and endometrial tumors. Dis Markers. 20(4-5):207-13. 3. Kawakami H, Zaanan A and Sinicrope FA (2015):Microsatellite instability testing and its role in the management of colorectal cancer. Curr Treat Options Oncol. 16(7):30

Caractéristiques

Type

Recombinant monoclonal rabbit/mouse antibody

Clone

DA083

Isotype

Rabbit

Réactivité

Synthetic peptide from human MSH2

Localisation

Nucleus

Usage prévu

IHC (FFPE)