MART-1/melan A Antibody (DA078)

Description

MART-1 (also known as melan A) is a melanoma antigen recognized by T cells.1-2 MART-1 is a transmembrane protein present in melanocytes of normal skin, nevi, and most melanomas. MART-1 is a useful marker for identifying melanomas.3-11 It is mainly used for the diagnosis and differential diagnosis of malignant melanoma and tumors accompanied by melanocytic differentiation. — Références — 1. Kawakami, Y et al. "Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor." Proceedings of the National Academy of Sciences of the United States of America vol. 91,9 (1994): 3515-9. 2. Coulie, P G et al. "A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas." The Journal of experimental medicine vol. 180,1 (1994): 35-42. 3. Kageshita, T et al. "Differential expression of MART-1 in primary and metastatic melanoma lesions." Journal of immunotherapy (Hagerstown, Md. : 1997) vol. 20,6 (1997): 460-5. 4. Fetsch, P A et al. "Melanoma-associated antigen recognized by T cells (MART-1): the advent of a preferred immunocytochemical antibody for the diagnosis of metastatic malignant melanoma with fine-needle aspiration." Cancer vol. 87,1 (1999): 37-42. 5. Bergman, R et al. "A comparative immunohistochemical study of MART-1 expression in Spitz nevi, ordinary melanocytic nevi, and malignant melanomas." Journal of the American Academy of Dermatology vol. 42,3 (2000): 496-500. 6. Orosz, Z. "Melan-A/Mart-1 expression in various melanocytic lesions and in non-melanocytic soft tissue tumours." Histopathology vol. 34,6 (1999): 517-25. 7. Yaziji, Hadi, and Allen M Gown. "Immunohistochemical markers of melanocytic tumors." International journal of surgical pathology vol. 11,1 (2003): 11-5. 8. Suchak, Ravi et al. "Evaluation of the role of routine melan-A immunohistochemistry for exclusion of microinvasion in 120 cases of lentigo maligna." The American Journal of dermatopathology vol. 36,5 (2014): 387-91. 9. Helm, Klaus, and Jennifer Findeis-Hosey. "Immunohistochemistry of pigmented actinic keratoses, actinic keratoses, melanomas in situ and solar lentigines with Melan-A." Journal of cutaneous pathology vol. 35,10 (2008): 931-4. 10. Kucher, Cynthia et al. "Expression of Melan-A and Ki-67 in desmoplastic melanoma and desmoplastic nevi." The American Journal of dermatopathology vol. 26,6 (2004): 452-7. 11. Nielsen, Patricia Switten et al. "Immunohistochemical double stains against Ki67/MART1 and HMB45/MITF: promising diagnostic tools in melanocytic lesions." The American Journal of dermatopathology vol. 33,4 (2011): 361-70.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA078

Isotype

Rabbit

Réactivité

Synthetic peptide of human MART-1/melan A

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)