Mammaglobin Antibody (DA018)

Description

Mammaglobin is a breast-associated glycoprotein distantly related to the secretoglobin family that includes human uteroglobin and lipophilin.1,2 Anti-mammaglobin labels cytoplasm of normal breast and sweat gland epithelial cells.3 Its expression is also demonstrated in primary and metastatic breast carcinomas.1-5. Absence of mammaglobin expression is typically seen in prostate, kidney, colon, rectum, small intestine, stomach, pancreas, lung and thyroid tissues.2,6 Mammaglobin may be used as one of the breast lineage markers for the origin estimation of carcinomas of unknown primary.2,4 — Références — 1. Fleming, T P, and M A Watson. "Mammaglobin, a breast-specific gene, and its utility as a marker for breast cancer." Annals of the New York Academy of Sciences vol. 923 (2000): 78-89. 2. Bhargava, Rohit et al. "Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity." American journal of clinical pathology vol. 127,1 (2007): 103-13. 3. Sjödin, Anna et al. "Mammaglobin in normal human sweat glands and human sweat gland tumors." The Journal of investigative dermatology vol. 121,2 (2003): 428-9. 4. Wang, Zhiqiang et al. "Mammaglobin, a valuable diagnostic marker for metastatic breast carcinoma." International journal of clinical and experimental pathology vol. 2,4 (2009): 384-9. 5. Han, Jae-Ho et al. "Mammaglobin expression in lymph nodes is an important marker of metastatic breast carcinoma." Archives of pathology & laboratory medicine vol. 127,10 (2003): 1330-4. 6. Zafrakas, Menelaos et al. "Expression analysis of mammaglobin A (SCGB2A2) and lipophilin B (SCGB1D2) in more than 300 human tumors and matching normal tissues reveals their co-expression in gynecologic malignancies." BMC cancer vol. 6 88. 9 Apr. 2006.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA018

Isotype

Mouse

Réactivité

Synthetic peptide of human Mammaglobin

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)