INI-1 Antibody (DA170)

Description

INI-1, also known as SMARCB1, is one of the core subunit proteins of the ATP-dependent SWI/SNF chromatin remodeling complex. It is involved in chromatin remodeling and transcriptional regulation and functions as a tumor suppressor. Nuclear INI-1 expression is seen in virtually all normal human tissues and most malignancies but the INI-1 gene is often mutated or deleted in malignant rhabdoid tumors (MRT), including those arising in the central nervous system, leading to a lack of INI-1 expression.1-3 — Références — 1. Bourdeaut, F et al. "hSNF5/INI1-deficient tumours and rhabdoid tumours are convergent but not fully overlapping entities." The Journal of pathology vol. 211,3 (2007): 323-30. 2. Kohashi, Kenichi, and Yoshinao Oda. "Oncogenic roles of SMARCB1/INI1 and its deficient tumors." Cancer science vol. 108,4 (2017): 547-552. 3. Haberler, Christine et al. "Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype." The American journal of surgical pathology vol. 30,11 (2006): 1462-8.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA170

Isotype

Rabbit

Réactivité

Synthetic peptide of human INI-1

Localisation

Nucleus

Usage prévu

IHC (FFPE)