Inhibin-α Antibody (DA074)

Description

Inhibin is a peptide hormone that inhibits FSH secretion from the pituitary.1-2 Inhibin is a dimer that consists of an alpha and beta subunit.1-2 Inhibin is mainly expressed in ovarian granulosa cell, theca cell and granulosa cell tumors, Sertoli-Leydig cell tumor and hepatocellular carcinoma. In normal tissue, anti-inhibin alpha labels granulosa cells of the ovary, sertoli and leydig cells of the testis, and the zona reticularis of the adrenal cortex.2 Anti-inhibin alpha has demonstrated utility in the identification of sex cord stromal tumors and adrenal cortical tumors.3-9 — Références — 1. Munro LM, et al. The expression of inhibin/activin subunits in the human adrenal cortex and its tumours. J Endocrinol. 1999; 161:341-7. 2. McCluggage WG, et al. Immunohistochemical staining of normal, hyperplastic, and neoplastic adrenal cortex with a monoclonal antibody against alpha inhibin. J Clin Pathol. 1998; 51:114-6. 3. Stewart CJ, et al. Diagnostic value of inhibin immunoreactivity in ovarian gonadal stromal tumours and their histological mimics. Histopathology. 1997; 31:67-74. 4. Yamashita K, et al. Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. Am J Obstet Gynecol. 1997; 177:1450-7. 5. McCluggage WG, et al. Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody. Am J Surg Pathol. 1998; 22:615-9. 6. Kommoss F, et al. Inhibin expression in ovarian tumors and tumor-like lesions: an immunohistochemical study. Mod Pathol. 1998; 11:656-64. 7. Iczkowski KA, et al. Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors. Mod Pathol. 1998; 11:774-9. 8. Guerrieri C, et al. Ovarian endometrioid carcinomas simulating sex cord-stromal tumors: a study using inhibin and cytokeratin 7. Int J Gynecol Pathol. 1998; 17:266-71. 9. McCluggage WG. Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms. J Clin Pathol. 2000; 53:327-34.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA074

Isotype

Mouse

Réactivité

Synthetic peptide from human Inhibin, alpha

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)