Glypican-3 Antibody (DA064)

Description

Glypican-3 (GPC3) is a membrane-bound heparin sulfate proteoglycan known to participate in cell growth and differentiation.1 GPC3 expression has been observed in the majority of hepatocellular carcinomas (HCC), but is rarely expressed in non-neoplastic hepatic tissue, making it a useful marker for HCC.1-3 Additionally, this marker is expressed in many yolk sac tumors.1,4 — Références — 1. Kandil DH, et al. Glypican-3 a novel diagnostic marker for hepatocellular carcinoma and more. Adv Anat Pathol. 2009; 16:125-9. 2. Coston WMP, et al. Distinction of hepatocellular carcinoma from benign hepatic mimickers using Glypican-3 and CD34 immunohistochemistry. Am J Surg Pathol. 2008; 32:433-44. 3. Capurro M, et al. Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma. Gastroenterology. 2003; 125:89-97. 4. Zynger DL, et al. Glypican 3: a novel marker in testicular germ cell tumors. Am J Surg Pathol. 2006; 30:1570-5.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA064

Isotype

Mouse

Réactivité

Synthetic peptide of human Glypican 3

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)