GCDFP-15 Antibody (DA061)

Description

Gross cystic disease fluid protein 15 (GCDFP-15) is a glycoprotein localized in the apocrine metaplastic epithelium lining breast cysts and in apocrine glands in the axilla, vulva, eyelid, ear canal, and in salivary glands.1-3 It is not present in normal ductal or lobular epithelium but is present in apocrine metaplasia in the breast. GCDFP-15 positivity is seen in breast carcinomas but not in other common carcinomas such as lung or colorectal carcinoma.4-8 — Références — 1. Mazoujian, G, and R Margolis. "Immunohistochemistry of gross cystic disease fluid protein (GCDFP-15) in 65 benign sweat gland tumors of the skin." The American Journal of dermatopathology vol. 10,1 (1988): 28-35. 2. Ansai, S et al. "An immunohistochemical study of lysozyme, CD-15 (Leu M1), and gross cystic disease fluid protein-15 in various skin tumors. Assessment of the specificity and sensitivity of markers of apocrine differentiation." The American Journal of dermatopathology vol. 17,3 (1995): 249-55. 3. Mazoujian, G et al. "Immunohistochemistry of a gross cystic disease fluid protein (GCDFP-15) of the breast. A marker of apocrine epithelium and breast carcinomas with apocrine features." The American journal of pathology vol. 110,2 (1983): 105-12. 4. Wick, M R et al. "Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin." Human pathology vol. 20,3 (1989): 281-7. 5. Liegl, B et al. "Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases." Histopathology vol. 50,4 (2007): 439-47. 6. Bhargava, Rohit et al. "Mammaglobin vs GCDFP-15: an immunohistologic validation survey for sensitivity and specificity." American journal of clinical pathology vol. 127,1 (2007): 103-13. 7. Tornos, Carmen et al. "Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary." The American journal of surgical pathology vol. 29,11 (2005): 1482-9. 8. Takeda, Yuji et al. "Analysis of expression patterns of breast cancer-specific markers (mammaglobin and gross cystic disease fluid protein 15) in lung and pleural tumors." Archives of pathology & laboratory medicine vol. 132,2 (2008): 239-43.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA061

Isotype

Rabbit

Réactivité

Synthetic peptide of human GCDFP-15

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)