Galectin-3 Antibody (DA059)

Description

Galectin-3 is a 30-kD protein, a member of the beta-galactosidase-binding lectin family. Galectin-3 is associated with cell growth, adhesion, inflammation, mRNA processing, and apoptosis.1-2 Reportedly, Galectin-3 aberrant expression is related to malignant transformation and metastasis in carcinomas of the breast, colon and thyroid.3-5 Galectin-3 reactivity can be seen in the nucleus of neutrophils, vascular endothelium, carcinomas of the colon, breast, and thyroid. Galectin-3 may be useful in the differentiation of benign and malignant thyroid neoplasms.6-7 Galectin-3 may also be useful in the identification of certain liver disorders.8 — Références — 1. Inohara H, et al. Expression of galectin-3 in fine-needle aspirates as a diagnostic marker differentiating benign from malignant thyroid neoplasms. Cancer. 1999; 85:2475-84. 2. Herrmann ME, et al. Immunohistochemical expression of galectin-3 in benign and malignant thyroid lesions. Arch Pathol Lab Med. 2002; 126:710-3. 3. Papotti M, et al. Role of galectin-3 immunodetection in the cytological diagnosis of thyroid cystic papillary carcinoma. Eur J Endocrinol. 2002; 147: 515-21. 4. Bartolazzi A, et al. Application of an immunodiagnostic method for improving preoperative diagnosis of nodular thyroid lesions. Lancet. 2001; 357:1644-50. 5. Orlandi F, et al. Galectin-3 is a presurgical marker of human thyroid carcinoma. Cancer Res. 1998; 58:3015-20. 6. Gasbarri A, et al. Galectin-3 and CD44v6 isoforms in the preoperative evaluation of thyroid nodules. J Clin Oncol. 1999; 17:3494-502. 7. Chiu CG, et al. Diagnostic utility of galectin-3 in thyroid cancer. Am J Pathol. 2010; 176:2067-81. 8. Hsu DK, et al. Galectin-3 expression is induced in cirrhotic liver and hepatocellular carcinoma. Int J Cancer. 1999; 81:519-26.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA059

Isotype

Rabbit

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)