FLI-1 Antibody (DA057)

Description

Friend leukemia integration 1 transcription factor (FLI-1) is a protein encoded by the proto-ocogene FLI-1. The FLI-1 protein is best known for its critical role in the pathogenesis of ES/pPNET. FLI-1 is normally expressed in endothelial cells and in hematopoietic cells, including T-lymphocytes. The immunohistochemical detection of FLI-1 protein has been shown in studies to be valuable in the discrimination of Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/pPNET) from most of its potential mimics. ES/pPNET is a rare primary tumor of the bone/soft tissue that resembles other undifferentiated tumors.1-3 — Références — 1. Mhawech-Fauceglia P, et al. Histopathology. 2006; 49:569-75. 2. Kuroda N, et al. Med Mol Morphol. 2006; 39:221-5. 3. Ellison DA, et al. Hum Pathol. 2007; 38:205-11.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA057

Isotype

Mouse

Réactivité

Synthetic peptide of human FLI-1

Localisation

Nucleus

Usage prévu

IHC (FFPE)