Epstein-Barr Virus Antibody (DA154)

Description

The Epstein-Barr virus, also called Human Herpesvirus 4, is a virus of the Herpes family, and is one of the most common viruses in humans. The virus can execute many distinct programs of gene expression, which can be broadly categorized as being lytic cycle or latent cycle. The lytic cycle, or productive infection, results in staged expression of several viral proteins with the ultimate objective of producing infectious virions. The latent cycle (lysogenic) programs are those that do not result in production of virions. A very limited, distinct set of viral proteins are produced during latent cycle infection. These include Epstein Barr nuclear antigens EBNA-1, EBNA-2, EBNA-3A, EBNA-3B, EBNA-3C, EBNA-leader protein (EBNA-LP), latent membrane proteins LMP-1, LMP-2A and LMP-2B and the Epstein-Barr encoded RNAs (EBERs). In addition, EBV codes for at least twenty microRNAs which are expressed in latently infected cells.1-5 — Références — 1. Murray PG, et al. J Pathol. 1992;166:1-5 2. Jarrett RF, et al. Blood. 1991;78:1-10 3. Pailesen G, et al. Lancet. 1991;337:320-322 4. Silverberg GS, et al. Principles and Practice of Surgical Pathology and Cytopathology, 3rd edition. 1997 5. U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories. Supplement / Vol. 61, January 6, 2012. https://www.cdc.gov/mmwr/pdf/other/su6101.pdf

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA154

Isotype

Mouse

Réactivité

Synthetic peptide of human Epstein-Barr Virus

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)