Ep-CAM Antibody (DA056)

Description

Epithelial cell adhesion molecule (Ep-CAM) is a transmembrane glycoprotein localized on the membrane of cells in most epithelial tissues.1 Immunoreactivity with the antibody to Ep-CAM has been seen in the majority of epithelial neoplasms, whereas most non-epithelial neoplasms do not show Ep-CAM expression.2 Ep-CAM is not expressed in mesothelial cells, hepatocytes, and lymphocytes.1,2 In conjunction with other markers, Ep-CAM can be used as an aid in determining epitheilial origin of neoplasms such as lung adenocarcinoma.2-4 It also labels synovial sarcomas and desmoplastic small round cell tumors. — Références — 1. Schnell, Ulrike et al. "EpCAM: structure and function in health and disease." Biochimica et biophysica acta vol. 1828,8 (2013): 1989-2001. 2. Latza, U et al. "Ber-EP4: new monoclonal antibody which distinguishes epithelia from mesothelial." Journal of clinical pathology vol. 43,3 (1990): 213-9. 3. Ordóñez, N G. "Value of the Ber-EP4 antibody in differentiating epithelial pleural mesothelioma from adenocarcinoma. The M.D. Anderson experience and a critical review of the literature." American journal of clinical pathology vol. 109,1 (1998): 85-9. 4. Ordóñez, Nelson G. "The immunohistochemical diagnosis of mesothelioma: a comparative study of epithelioid mesothelioma and lung adenocarcinoma." The American journal of surgical pathology vol. 27,8 (2003): 1031-51.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA056

Isotype

Mouse

Réactivité

Synthetic peptide from human Ep-CAM

Localisation

Cell membrane

Usage prévu

IHC (FFPE)