EGFR Antibody (DA054)

Description

Epidermal Growth Factor Receptor (EGFR) is the receptor for epidermal growth factor (EGF). It is a member of the ErbB family receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER-2 neu (ErbB-2), HER-3 (ErbB-3) and HER-4 (ErbB-4). 1-4 Ninety percent of EGFR mutations in lung adenocarcinoma occur with the L858R mutation in exon 21 and the E764-A705del deletion in exon 19.EGFR(SP111) can be used to screen lung adenocarcinoma cases with E764-A705del deletion. — Références — 1. Cohen S, et al. J Biol Chem. 1982;257:1523 2. Ozane B, et al. J Pathol. 1986; 149:191 3. Niikura H, et al. Human Pathol. 1996; 27:282 4. U.S. Department of Health and Human Services: Centers for Disease Control and Prevention. Guidelines for Safe Work Practices in Human and Animal Medical Diagnostic Laboratories. Supplement / Vol. 61, January 6, 2012. https://www.cdc.gov/mmwr/pdf/other/su6101.pdf

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA054

Isotype

Rabbit

Réactivité

Synthetic peptide from human EGFR

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)