E-Cadherin Antibody (DA053)

Description

E-cadherin is a transmembrane protein that is involved in cell adhesion through the formation of adherens junctions between cells. It is expressed in cells of epithelial lineage. Anti-E-cadherin stains positively in glandular epithelium as well as carcinomas of the gastrointestinal tract1 and breast. E-cadherin immunohistochemistry may also aid in the differentiation of breast ductal carcinomas (with membranous stain) from lobular carcinomas (with loss of the membranous stain)2,3. — Références — 1. Karayiannakis, A J et al. "E-cadherin expression as a differentiation marker in gastric cancer." Hepato-gastroenterology vol. 45,24 (1998): 2437-42. 2. Wahed, Amer et al. "E-cadherin expression in pleomorphic lobular carcinoma: an aid to differentiation from ductal carcinoma." Annals of diagnostic pathology vol. 6,6 (2002): 349-51. 3. Acs, G et al. "Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications." American journal of clinical pathology vol. 115,1 (2001): 85-98.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA053

Isotype

Rabbit

Réactivité

Synthetic peptide of human E-Cadherin

Localisation

Cytoplasm/Cell membrane

Usage prévu

IHC (FFPE)