Desmin Antibody (DA052)

Description

Anti-desmin detects a protein that is expressed by cells of normal smooth, skeletal, and cardiac muscles. It has been suggested that desmin is primarily located at or near the periphery of Z lines in striated muscle fibrils.1 In smooth muscle, desmin interconnects cytoplasmic dense bodies with membrane bound dense plaques. Anti-desmin reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.1-4 This antibody is used to demonstrate the myogenic components/derivation of tumors.2,3 Desmin can also be present in myofibroblasts and be focally positive in desmoid fibromatosis.4 High temperature repair can enhance the staining intensity. — Références — 1. Kouloumenta A, et al. Proper perinuclear localization of the TRIM-like protein myospryn requires its binding partner desmin. Journal of Biological Chemistry. 2007; 282:35211-21. 2. Altmannsberger M, et al. Desmin is a specific marker for rhabdomyosarcomas of human and rat origin. Am J Pathol 1985; 118:85-95. 3. Debus E, et al. Monoclonal antibodies to desmin, the muscle-specific intermediate filament protein. EMBO J. 1983; 2:2305-12. 4. Yamaguchi U, et al. Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis. Virchows Arch. 2004; 2:142-50.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA052

Isotype

Rabbit

Réactivité

Synthetic peptide from human desmin

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)