Cytokeratin CAM 5.2 Antibody (DA126)

Description

CAM5.2, also known as very low molecular weight cytokeratin, recognizes 48 and 52 kDa human cytokeratins, corresponding to Moll classifications CK7 and CK8, but with a relatively weak response to CK7. Anti-CAM 5.2 reacts with cytokeratins 7 and 8, which are expressed in simple and glandular epithelia and transitional epithelium. Anti-CAM 5.2 reacts with most normal epithelium and with most carcinomas, including those arising in lung, liver, pancreas, GI tract, breast, genitourinary system, female reproductive organs and some endocrine organs.1,2 This antibody can be used as an aid to identify epithelial differentiation in normal and neoplastic tissues. — Références — 1. Ordóñez, Nelson G. "Broad-spectrum immunohistochemical epithelial markers: a review." Human pathology vol. 44,7 (2013): 1195-215. 2. Pan, Chin-Chen et al. "Differential immunoprofiles of hepatocellular carcinoma, renal cell carcinoma, and adrenocortical carcinoma: a systemic immunohistochemical survey using tissue array technique." Applied immunohistochemistry & molecular morphology : AIMM vol. 13,4 (2005): 347-52.

Caractéristiques

Type

Recombinant monoclonal mouse antibody

Clone

DA126

Isotype

Mouse

Réactivité

Synthetic peptide of human Cytokeratin CAM5.2

Localisation

Nucleus

Usage prévu

IHC (FFPE)