Cytokeratin 8 &18 Antibody (DA047)

Description

Cytokeratins 8 &18 (CK 8 & 18) are major components of the intermediate filaments in thyroid, liver and most simple epithelia (e.g. breast, gastrointestinal and respiratory tracts).1-2 Anti-CK 8 & 18 is found to stain most adenocarcinomas and squamous cell carcinomas.3-5 CK 8 & 18 are frequently used as the epithelial markers for identifying Paget cells,6 metastatic gastric7 and colorectal carcinomas.8 — Références — 1. Franke, W W et al. "Diversity of cytokeratins. Differentiation specific expression of cytokeratin polypeptides in epithelial cells and tissues." Journal of molecular biology vol. 153,4 (1981): 933-59. 2. Oshima, R G et al. "Oncogenic regulation and function of keratins 8 and 18." Cancer metastasis reviews vol. 15,4 (1996): 445-71. 3. Angus, B et al. "NCL-5D3: a new monoclonal antibody recognizing low molecular weight cytokeratins effective for immunohistochemistry using fixed paraffin-embedded tissue." The Journal of pathology vol. 153,4 (1987): 377-84. 4. Corson, J M. "Keratin protein immunohistochemistry in surgical pathology practice." Pathology annual vol. 21 Pt 2 (1986): 47-81. 5. Moll, Roland et al. "The human keratins: biology and pathology." Histochemistry and cell biology vol. 129,6 (2008): 705-33. 6. Liegl, B et al. "Mammary and extramammary Paget's disease: an immunohistochemical study of 83 cases." Histopathology vol. 50,4 (2007): 439-47. 7. Ishii, Kaname et al. "Detection of sentinel and non-sentinel lymph node micrometastases by complete serial sectioning and immunohistochemical analysis for gastric cancer." Journal of experimental & clinical cancer research : CR vol. 27,1 7. 30 May. 2008. 8. Sasaki, M et al. "Immunoperoxidase staining for cytokeratins 8 and 18 is very sensitive for detection of occult node metastasis of colorectal cancer: a comparison with genetic analysis of K-ras." Histopathology vol. 32,3 (1998): 199-208.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA047

Isotype

Rabbit

Réactivité

Synthetic peptide of human Cytokeratin 8&18

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)