Cytokeratin 7 Antibody (DA046)

Description

Anti-cytokeratin 7 reacts with proteins that are found in most ductal, glandular, transitional, and biliary duct epithelial cells. Cytokeratin 7 (CK7) labeling can help distinguish between lung,1 breast carcinomas, and urothelial carcinomas that typically stain positive, and colon and prostate carcinomas that typically lack CK7 expression.2-7 CK7 is a common marker of primary lung adenocarcinomas and is observed in other primary lung carcinomas and non-pulmonary carcinomas.1 Anti-cytokeratin 7 has also been useful in the differential diagnosis of ovarian neoplasms.8 — Références — 1. Jerome Marson, V et al. "Expression of TTF-1 and cytokeratins in primary and secondary epithelial lung tumours: correlation with histological type and grade." Histopathology vol. 45,2 (2004): 125-34. 2. Murray, Shawn K et al. "Spread of prostate carcinoma to the perirectal lymph node basin: analysis of 112 rectal resections over a 10-year span for primary rectal adenocarcinoma." The American journal of surgical pathology vol. 28,9 (2004): 1154-62. 3. Chu, P et al. "Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 13,9 (2000): 962-72. 4. Logani, Sanjay et al. "Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers: histogenetic and diagnostic implications." The American journal of surgical pathology vol. 27,11 (2003): 1434-41. 5. Ramalingam, Preetha et al. "Invasive micropapillary carcinoma of the breast metastatic to the urinary bladder and endometrium: diagnostic pitfalls and review of the literature of tumors with micropapillary features." Annals of diagnostic pathology vol. 7,2 (2003): 112-9. 6. Roy, Somak, and Anil V Parwani. "Adenocarcinoma of the urinary bladder." Archives of pathology & laboratory medicine vol. 135,12 (2011): 1601-5. 7. Han, A C, and R Duszak Jr. "Coexpression of cytokeratins 7 and 20 confirms urothelial carcinoma presenting as an intrarenal tumor." Cancer vol. 86,11 (1999): 2327-30. 8. McCluggage, W G, and N Wilkinson. "Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features." Histopathology vol. 47,3 (2005): 231-47.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA046

Isotype

Rabbit

Réactivité

Synthetic peptide of Cytokeratin 7

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)