Cytokeratin 5&6 Antibody (DA045)

Description

Twenty identified cytokeratins make up a complex family of intermediate filaments.1 Cytokeratin 5 (58kDa) & cytokeratin 6 (56kDa) are type II high molecular weight keratins that are expressed in a broad range of normal tissues including breast, prostate, mesothelium, skin and esophagus.1-3 Anti-Cytokeratin 5 & 6 is a useful immunohistochemical marker in the identification of mesothelioma and lung squamous cell carcinoma.1 Combined with 34bE12 and P504S, it can help diagnosis of benign and malignant prostate lesions. — Références — 1. Ordóñez NG. Value of cytokeratin 5/6 immunostaining in distinguishing epithelial mesothelioma of the pleura from lung adenocarcinoma. Am J Surg Pathol. 1998; 22:1215-21 2. Takahashi K, et al. Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms. J Biol Chem. 1995; 270:18581-92. 3. Lersch R, et al. Isolation, sequence, and expression of a human keratin K5 gene: transcriptional regulation of keratins and insights into pairwise control. Mol Cell Biol. 1989; 9:3685-97.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA045

Isotype

Rabbit

Réactivité

Synthetic peptide of human Cytokeratin 5&6

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)