Cytokeratin 20 Antibody (DA044)

Description

Cytokeratin 20 is a 46-kDa intermediate filament protein which reacts primarily with gastric and intestinal epithelium, urothelium, and Merkel cells.1-4 Anti-Cytokeratin 20 is useful in the identification of specific types of these epithelial cells under normal, hyperplastic, and neoplastic conditions.3 Cytokeratin 20 has been detected in various adenocarcinomas, including those of the colon and stomach.5-7 Merkel cell carcinomas have shown reactivity. In contrast, carcinomas of the breast are generally non-reactive. — Références — 1. Moll R, et al. Identification of protein IT of the intestinal cytoskeleton as a novel type 1 cytokeratin with unusual properties and expression patterns. J Cell Biol. 1990; 111:567-80. 2. Moll R, et al. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell. 1982; 31:11-24. 3. Han AC, Duszak R Jr. Coexpression of cytokeratins 7 and 20 confirms urothelial carcinoma presenting as an intrarenal tumor. Cancer. 1999; 86:2327-30. 4. Moll R, et al. Cytokeratin 20 in human carcinomas: a new histodiagnostic marker detected by monoclonal antibodies. AJP. 1992; 140:427-47. 5. Tot T. Adenocarcinomas metastatic to the liver: the value of cytokeratins 20 and 7 in search for unknown primary tumors. Cancer 1999; 85:171-7. 6. Lau SK, et al. Comparative immunohistochemical profile of hepatocellular carcinoma, cholangiocarcinoma, and metastatic adenocarcinoma. Hum Pathol. 2002; 33:1175-81. 7. Rullier A et al. Cytokeratin 7 and 20 expression in cholangiocarcinomas varies along the biliary tract but still differs from that in colorectal carcinoma metastasis. Am J Surg Pathol. 2000; 24:870-6.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA044

Isotype

Rabbit

Réactivité

Synthetic peptide of human Cytokeratin 20

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)