Chromogranin A Antibody (DA037)

Description

Chromogranin A is a group of soluble acidic cytosolic proteins with a molecular weight of 76-120 kDa. Immunohistochemical methods have localized chromogranin in a wide variety of endocrine tissues including the pituitary, pancreas, thyroid, and parathyroid.1-3 Neuroendocrine cells exhibit a fine granular immunoreactivity to chromogranin.1-3 It is generally accepted that the co-expression of certain keratins and chromogranin mean neuroendocrine lineage. The presence of strong chromogranin staining and absence of keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. — Références — 1. Fischer-Colbrie R, et al. Immunological studies on the distribution of chromogranin A and B in endocrine and nervous tissues. Neuroscience. 1985; 16:547-55. 2. Hearn SA. Electron microscopic localization of chromogranin A in osmium-fixed neuroendocrine cells with a protein A-gold technique. J Histochem Cytochem. 1987; 35:795-801. 3. Wilson BS, et al. Detection of chromogranin in neuroendocrine cells with a monoclonal antibody. Am J Pathol. 1984; 115:458-68.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA037

Isotype

Rabbit

Réactivité

Synthetic peptide from human Chromogranin A

Localisation

Cytoplasm

Usage prévu

IHC (FFPE)