CDX-2 Antibody (DA035)

Description

CDX-2 is a caudal-related homeobox transcription factor that plays a role in the development and maintenance of intestinal mucosa. It is expressed early in intestinal development and is involved in the regulation of intestinal epithelial cell proliferation and differentiation, localized to the villi and crypt surfaces of the intestinal epithelium. CDX2 deficiency promotes the development of sporadic colon cancers, and is also a distinguishing feature of large-cell, poorly-differentiated colon cancers. This protein is expressed in normal and neoplastic gastrointestinal epithelium, including colorectal adenocarcinoma. It is useful for identifying gastrointestinal origin of benign and malignant lesions.1-7 — Références — 1. Mazziotta, Robert M et al. "CDX2 immunostaining as a gastrointestinal marker: expression in lung carcinomas is a potential pitfall." Applied immunohistochemistry & molecular morphology : AIMM vol. 13,1 (2005): 55-60. 2. Erickson, Lori A et al. "Cdx2 as a marker for neuroendocrine tumors of unknown primary sites." Endocrine pathology vol. 15,3 (2004): 247-52. 3. Saqi, Anjali et al. "Usefulness of CDX2 and TTF-1 in differentiating gastrointestinal from pulmonary carcinoids." American journal of clinical pathology vol. 123,3 (2005): 394-404. 4. Saad, Reda S et al. "Usefulness of Cdx2 in separating mucinous bronchioloalveolar adenocarcinoma of the lung from metastatic mucinous colorectal adenocarcinoma." American journal of clinical pathology vol. 122,3 (2004): 421-7. 5. Kaimaktchiev, Vassil et al. "The homeobox intestinal differentiation factor CDX2 is selectively expressed in gastrointestinal adenocarcinomas." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 17,11 (2004): 1392-9. 6. Werling, Robert W et al. "CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: an immunohistochemical survey of 476 primary and metastatic carcinomas." The American journal of surgical pathology vol. 27,3 (2003): 303-10. 7. Moskaluk, Christopher A et al. "Cdx2 protein expression in normal and malignant human tissues: an immunohistochemical survey using tissue microarrays." Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc vol. 16,9 (2003): 913-9.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA035

Isotype

Rabbit

Réactivité

Synthetic peptide of human CDX-2

Localisation

Nucleus

Usage prévu

IHC (FFPE)