CD8 Antibody (DA033)

Description

The CD8 (cluster of differentiation 8) antigen is a cell surface glycoprotein made up of two subunits alpha and beta.1 Anti-CD8 is a T-cell marker for the detection of cytotoxic/suppressor lymphocytes.2 CD8 is also detected on NK cells, some thymocytes, some null cells and bone marrow cells. This antibody, along with other markers, can be used to distinguish between reactive and neoplastic T-cells.3 CD8 expression has been found to be negative in Mycosis Fungoides.4 Rarely does anti-CD8 label non-hematolymphoid neoplasms.5 — Références — 1. Gao G, et al. Molecular interactions of coreceptor CD8 and MHC class I: the molecular basis for functional coordination with T-cell receptor. Immunology Today. 2000; 21:630-6. 2. Kavathas P, et al. Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and Cdna subtraction. Proc. Natl. Acad. Sci. 1984; 81:7688-92. 3. Dabbs DJ. Diagnostic Immunohistochemistry. Fourth Edition. Saunders. 2006; p. 134-135. 4. Bakels V, et al. Immunophenotyping and gene rearrangement analysis provide additional criteria to differentiate between cutaneous T-cell lymphomas and pseudo-T-cell lymphomas. Am J Pathol. 1997; 150:1941-9 5. Chu PG, et al. Expression of T/NK-cell and plasma cell antigens in nonhematopoietic epithelioid neoplasms. An immunohistochemical study of 447 cases. Am J Clin Pathol. 2003; 120:64-70.

Caractéristiques

Type

Recombinant monoclonal rabbit antibody

Clone

DA033

Isotype

Rabbit

Réactivité

Synthetic peptide of human CD8

Localisation

Cell membrane

Usage prévu

IHC (FFPE)